Utrecht University

Biomedical Solid-State NMR

Utrecht University

Selected Recent Publications 

A. Shukla, R., Medeiros-Silva, J., Parmar, A., Vermeulen, B.J.A., Das, S.,  Paioni, L.A.,Jekhmane, S., Lorent, J., Bonvin, A.M.J.J., Baldus, M., Lelli, M., Veldhuizen, E., Breukink, E., Singh, I., Weingarth, M. (2020) Nature Communications, 11, 2848, Mode of action of teixobactins in cellular membranes See also press release

B. Jekhmane, S., Medeiros-Silva, J., Li, J., Kümmerer, F., Müller-Hermes, C., Baldus, M., Roux, B., Weingarth, M. (2019) Nature Communications, 10, 12 Shifts in the selectivity filter dynamics cause modal gating in K+ channels See also press release

C. Jekhmane, S., Prachar, M., J., Pugliese, R., Fontana, F., Medeiros-Silva, Gelain, F., Weingarth, M., (2019) Angewandte Chemie, 58, 16943, Design parameters of tissue engineering scaffolds at atomic scale

D. Medeiros-Silva, J., Jekhmane, S.,  Paioni, A., Gawarecka, K., Baldus, M., Swiezewska, E., Breukink, E., Weingarth, M. (2018) Nature Communications, 9, 3963, High-resolution NMR studies of antibiotics in cellular membranes  See also press release & coverage & coverage 



Publications 

  • 47.  van Eijk, M., Veldhuizen, E.J.A., van der Ent, C.K., Arets, HGM., van Dijk, A., Adrichem, A., van der Water, S., Gomez, R.L., Kristensen, M., Hessing, M., Jekhmane, S., Weingarth, M., Veldhuizen, R., Haagsman, HP.,  PepBiotics, a class of novel cathelicidin-inspired antimicrobials to fight pulmonary bacterial infections, to be submitted
  • 46. Zhai, W., Paioni, L.A., Cai, X., Narasimhan, S., Medeiros-Silva, J., Zhang, W., Rockenbauer, A., Weingarth, M., Song, Y., Baldus., M., Liu, Y., (2020) J. Chem. Phys., accepted, Postmodification via Thiol-click Chemistry yields Hydrophilic Trityl-Nitroxid Biradicals for Biomolecular High-Field Dynamic Nuclear Polarization 
  • 45. Lau, Y.J.L., Fontana, F., Mandemaker, L., Wezendonk, D., Vermeer, B., Bonvin, A., de Vries, R., Zhang, H., Remaut, K., van den Dikkenburg, J., Medeiros-Silva, J., Hassan, A., Perrone, B., Kuemmerle, R., Gelain, F., Hennink, W., Weingarth, M.,* Enrico Mastrobattista, E.*, (2020), Communications Chemistry, accepted, Control over the fibrillization yield by varying the oligomeric nucleation propensities of self-assembling peptides
  • 44. Shukla, R., Medeiros-Silva, J., Parmar, A., Vermeulen, B.J.A., Das, S.,  Paioni, L.A.,Jekhmane, S., Lorent, J., Bonvin, A.M.J.J., Baldus, M., Lelli, M., Veldhuizen, E., Breukink, E., Singh, I., Weingarth, M. (2020) Nature Comm., 11, 2848, Mode of action of teixobactins in cellular membranes
  • 43. Bear, B., Veldhuizen, J.A.E., Molchanova, N., Jekhmane, S., Weingarth., M., Jenssen, H., Lin, J.S., Barron, A.E., Yamashita, C., Veldhuizen, R. (2020) Scientific reports, 10, 9392, Optimizing Exogeneous Surfacant as a Pulmonary Delivery Vehicle for Chicken Cathelicidin-2
  • 42. Sarkar, D., Chakraborty, I., Condorelli, M., Baijayanti, G., Maass, T.,  Weingarth, M., Mandal, A.K., La Rosa, C., Subramanian, V., Bhunia, A., (2019) ChemMedChem, accepted, Self-assembly and Neurotoxicity of Amyloid-beta (21-40) Peptide fragment: The regulatory Role of GxxxG Motifs 
  • 41. Damman, R., Schütz, S., Luo, Y., Prachar, M., Weingarth, M., Sprangers, R., Baldus, M. (2019) Nature Comm., 10, 4536, Atomic-level insight into the maturated state of mRNA processing bodies by combining solid and solution-state NMR spectroscopy (open access)
  • 40. Jekhmane, S., Prachar, M., J., Pugliese, R., Fontana, F., Medeiros-Silva, Gelain, F., Weingarth, M., (2019) Angewandte Chemie, 58, 16943, Design parameters of tissue engineering scaffolds at atomic scale (open access)