Utrecht University

Biomedical Solid-State NMR

Utrecht University

Our research focuses on the structure - activity analysis of membrane-active antibiotics. These antibiotics are often not only active against multi-drug resistant bacteria, they are also refractory against antimicrobial resistance development.


Understanding these antibiotics compellingly requires studies in a natural lipid environment, and ideally cell membranes. And yup - modern solid-state NMR spectroscopy is uniquely suited for this task! But hold on: we not only do solid-state NMR (that would be easy). We also extensively study antibiotic binding affinities, produce antibiotics in bacteria, etc.


We study prominent antibiotics such as nisin (paper) or teixobactin (paper) and many others, often in collaboration with synthetic chemists to do drug design.