Utrecht University

Biomedical Solid-State NMR

Utrecht University

Weingarth lab

We use advanced solid-state NMR methods to study antibiotics in medically relevant conditions.

Selected Recent Publications

1.  Rohaim, A., Vermeulen, B., Li, J., Kümmerer, F., Napoli, F., Blachowicz, Medeiros-Silva, J., Roux., B., Weingarth, M., (2022) Nature Comm, 13, 1574, A distinct mechanism of C-type inactivation in the Kv-like KcsA mutant E71V

2. Shukla, R., Medeiros-Silva, J., Parmar, A., Vermeulen, B.J.A., Das, S.,  Paioni, L.A.,Jekhmane, S., Lorent, J., Bonvin, A.M.J.J., Baldus, M., Lelli, M., Veldhuizen, E., Breukink, E., Singh, I., Weingarth, M. (2020), Nature Communications, 11, 2848, Mode of action of teixobactins in cellular membranes

3. Jekhmane, S., Medeiros-Silva, J., Li, J., Kümmerer, F., Müller-Hermes, C., Baldus, M., Roux, B., Weingarth., M., (2019) Nature Comm., 10, 12, Shifts in the selectivity filter dynamics cause modal gating in K+ channels See also Press release

4. Medeiros-Silva, J., Jekhmane, S.,  Paioni, A., Gawarecka, K., Baldus, M., Swiezewska, E., Breukink, E., Weingarth, M., (2018Nature Comm., 9, 3963, High-resolution NMR studies of antibiotics in cell membranes  See here for the Press release & coverage & coverage

We have been awarded with an ERC Consolidator grant (2.000.000€)! (press release)

Several positions will become available soon (see Markus' Twitter @MarkusWeingarth for openings.

Mode of Action of Teixobactin in cellular membranes

Teixobactin, heralded as game-changer drug, could be one of our sharpest weapons against multi-drug resistant bacteria, however, before could use it in clinics, it requires chemical modifications.

Here we show the mode of action of teixobactin in cell membranes, including a HR structure, which could enable scientists worldwide to unlock the enormous potential of teixobactin for clinical applications.

Press release (English Dutch)

Nature Communications (2020), 11, 2848

High-resolution NMR studies of antibiotics in cellular membranes

A powerful NMR approach (integrating proton-detection and 800 MHz DNP) to study promising membrane-active antimicrobial peptides at high-resolution and directly in cellular conditions.

Press release (EnglishDutch)

Nature Communications (2018) 9, 3963

Video about the lab from 'Fundamental Connections' campaign of the Science Faculty. Thanks a lot to our faculty for the shoot, it was big fun!

Link to the Video.

Markus' recent ICMRBS webinar on antibiotics.