Utrecht University
Weingarth Lab
Biological Solid-State NMR
We use state-of-the-art solid-state NMR methods, often in combination with computational techniques, to study medically important biomolecules and biomaterials at the atomic level and at native (cellular) conditions. Our main research interests are:
Selected Recent Publications
1. Medeiros-Silva, J., Jekhmane, S., Paioni, A., Gawarecka, K., Baldus, M., Swiezewska, E., Breukink, E., Weingarth, M., (2018) Nature Comm., 9, 3963, High-resolution NMR studies of antibiotics in cell membranes See here for the Press release & coverage & coverage
2. Visscher, K.M., Medeiros-Silva, J. Mance, D., Rodrigues, J.P.G.L.M., Daniëls, M., Bonvin, A.M.J.J., Baldus, M., Weingarth, M., (2017) Angew. Chem., 56, 13222, Supramolecular organization and functional implications of K+ channel clusters in membranes Selected as Frontispiece
3. Medeiros-Silva, J., Mance, D., Daniels, M., Jekhmane, S., Houben, K., Baldus, M., Weingarth, M. (2016) Angew. Chem. 55, 13606, 1H-detected solid-state NMR of water-inaccessible proteins in vitro and in situ
4. Rad Malekshahi, M., Visscher. K.M., Rodrigues J.P.G.L.M., de Vries, R., Hennink, W.E., Baldus, M., Bonvin A.M.J.J., Mastrobattista E., Weingarth. M. (2015) J. Am. Chem. Soc., 137, 7775, The supramolecular organization of a peptide based nanocarrier at high molecular detail
5. Sinnige, T., Daniels, M., Baldus, M.,Weingarth, M. (2014) J. Am. Chem. Soc., 136, 4452, Proton clouds to measure non-exchangeable sidechain protons in solid-state NMR Article featured the Cover of JACS
João Medeiros-Silva et al.,
Nature Communications (2018)
9, 3963, p. 1-10
High-resolution NMR studies of antibiotics in cellular membranes
A powerful NMR approach (integrating proton-detection and 800 MHz DNP) to study promising membrane-active antimicrobial peptides at high-resolution and directly in cellular conditions.
Angewandte Chem. (2017)
56, 13222-13227
A DNP-ssNMR approach to study membrane protein - membrane protein interactions in relation to function in a FRET-like manner
