Weingarth lab
We use advanced solid-state NMR methods to study antibiotics in medically relevant conditions.
Selected Recent Publications
1. Rohaim, A., Vermeulen, B., Li, J., Kümmerer, F., Napoli, F., Blachowicz, Medeiros-Silva, J., Roux., B., Weingarth, M., (2022) Nature Comm, 13, 1574, A distinct mechanism of C-type inactivation in the Kv-like KcsA mutant E71V
2. Shukla, R., Medeiros-Silva, J., Parmar, A., Vermeulen, B.J.A., Das, S., Paioni, L.A.,Jekhmane, S., Lorent, J., Bonvin, A.M.J.J., Baldus, M., Lelli, M., Veldhuizen, E., Breukink, E., Singh, I., Weingarth, M. (2020), Nature Communications, 11, 2848, Mode of action of teixobactins in cellular membranes
3. Jekhmane, S., Medeiros-Silva, J., Li, J., Kümmerer, F., Müller-Hermes, C., Baldus, M., Roux, B., Weingarth., M., (2019) Nature Comm., 10, 12, Shifts in the selectivity filter dynamics cause modal gating in K+ channels See also Press release
4. Medeiros-Silva, J., Jekhmane, S., Paioni, A., Gawarecka, K., Baldus, M., Swiezewska, E., Breukink, E., Weingarth, M., (2018) Nature Comm., 9, 3963, High-resolution NMR studies of antibiotics in cell membranes See here for the Press release & coverage & coverage
We have been awarded with an ERC Consolidator grant (2.000.000€)! (press release)
Several positions will become available soon (see Markus' Twitter @MarkusWeingarth for openings.
Mode of Action of Teixobactin in cellular membranes
Teixobactin, heralded as game-changer drug, could be one of our sharpest weapons against multi-drug resistant bacteria, however, before could use it in clinics, it requires chemical modifications.
Here we show the mode of action of teixobactin in cell membranes, including a HR structure, which could enable scientists worldwide to unlock the enormous potential of teixobactin for clinical applications.
Press release (English & Dutch)
Nature Communications (2020), 11, 2848
High-resolution NMR studies of antibiotics in cellular membranes
A powerful NMR approach (integrating proton-detection and 800 MHz DNP) to study promising membrane-active antimicrobial peptides at high-resolution and directly in cellular conditions.
Press release (English & Dutch)
Nature Communications (2018) 9, 3963
Video about the lab from 'Fundamental Connections' campaign of the Science Faculty. Thanks a lot to our faculty for the shoot, it was big fun!