Utrecht University

Biomedical Solid-State NMR

Utrecht University

Weingarth Lab    

Biomedical Solid-State NMR

We use advanced solid-state NMR methods to study medically important biomolecules and biomaterials at the atomic level and directly in native cellular conditions. Our main research interests are:

  • Antibiotics
  • Tissue engineering
  • Ion channels

Selected Recent Publications 

1. Jekhmane, S., Medeiros-Silva, J., Li, J., Kümmerer, F., Müller-Hermes, C., Baldus, M., Roux, B., Weingarth., M., (2019) Nature Comm., 10, 12, Shifts in the selectivity filter dynamics cause modal gating in K+ channels See also Press release

2. Jekhmane, S., Prachar, M., J., Pugliese, R., Fontana, F., Medeiros-Silva, Gelain, F., Weingarth, M., (2019) Angewandte Chemie, in press, Design parameters of tissue engineering scaffolds at atomic scale

3. Medeiros-Silva, J., Jekhmane, S.,  Paioni, A., Gawarecka, K., Baldus, M., Swiezewska, E., Breukink, E., Weingarth, M., (2018Nature Comm., 9, 3963, High-resolution NMR studies of antibiotics in cell membranes  See here for the Press release & coverage & coverage

4. Visscher, K.M.,  Medeiros-Silva, J. Mance, D., Rodrigues, J.P.G.L.M., Daniëls, M., Bonvin, A.M.J.J., Baldus, M., Weingarth, M., (2017) Angew. Chem., 56, 13222, Supramolecular organization and functional implications of K+ channel clusters in membranes  Selected as Frontispiece 

Video about the lab from 'Fundamental Connections' campaign of the Science Faculty. Thanks a lot to our faculty for the shoot, it was big fun!

See here for the Video.

Shehrazade Jekhmane & João Medeiros-Silva  et al.,  Nature Communications (2019) 10, 12, p. 1-11 

Shifts in the selectivity filter dynamics cause modal gating in K+ channels

This work provides a long-needed quantitative description of the selectivity filter dynamics in a native environment, which is of fundamental importance to understand ion channel function

Press release 

João Medeiros-Silva  et al., 

Nature Communications (2018)

9, 3963, p. 1-10 

High-resolution NMR studies of antibiotics in cellular membranes

A powerful NMR approach (integrating proton-detection and 800 MHz DNP) to study promising membrane-active antimicrobial peptides at high-resolution and directly in cellular conditions.

Press release (EnglishDutch)

Koen Visscher et al. 

Angewandte Chem. (2017) 

56, 13222-13227

A DNP-ssNMR approach to study membrane protein - membrane protein interactions in relation to function in a FRET-like manner