K+ channels cluster in reference to their gating cycle
Using a combination of dynamic nuclear polarisation (DNP) enhanced solid-state NMR measurements in bacterial membranes and large-scale computer simulations, we could recently show that K+ channels aggregate and dissolve in reference to their gating cycle, uncovering a hitherto unknown mechanism of functional coupling between K+ channels.
Check out the paper in Angewandte Chemie: Visscher et al. 2017
K+ channels: unexpected conformational dynamics
The selectivity filter of potassium channels is highly conserved throughout bacteria and eukaryotes. Using modern 1H-detected solid-state NMR, we demonstrate that the conductive selectivity filter exhibits substantially increased slow microsecond motion. Such slow motion is on the same time-scale as thus far unexplained gating modes such as flickering.
Check out the paper in Angewandte Chemie: Medeiros-Silva et al. 2016
K+ channel - lipid interaction...